![]() ![]() The subdomains support the morphogenesis and orientation of the photosensitive membrane organelles: rhabdomeres and outer segments, respectively. (2002) showed that crumbs and CRB1 localize to corresponding subdomains of the photoreceptor apical plasma membrane: the stalk of the Drosophila photoreceptor and the inner segment of mammalian photoreceptors. Stardust proteins colocalize with crumbs and bind to the carboxy-terminal amino acids of its cytoplasmic tail. (2001) demonstrated that stardust provides an essential component of the subapical complex. Cells lacking crumbs or the functionally related gene 'stardust' fail to organize a continuous zonular adherens and to maintain cell polarity. A core component of the subapical complex is the transmembrane protein crumbs, the cytoplasmic domain of which recruits the PDZ protein Patj (603199) into the complex. It is followed by the zonula adherens, and, further basally, by the septate junction. The most apical one comprises the subapical complex. ![]() In epithelial cells of the Drosophila embryo, 3 distinct domains subdivide the lateral plasma membrane. The polarized architecture of epithelial cells depends on the highly stereotypic distribution of cellular junctions and other membrane-associated protein complexes. Industry Insights with Yuning Chen on Recombinant Proteins.ExpertAnswers: Yuning Chen on Antibody Production.Universal Vaccine Advancement through AI and Recombinant Technology.Nanobodies: An Important Tool for the Next Generation of Tumor Diagnostics and Therapeutics.ExpertAnswers: Amy Sheng on Antibody Screening and Discovery.Recombinant DNA Technology and Its Impact on Drug Discovery.CAR-T Cell Therapy Development: From Personalized to off the Shelf Approaches.Special Offer: Custom Recombinant Antibody Production Service.Common Cytokine Receptor Signaling Pathway.Beacon ® Single B Cell Screening Service.Recombinant Antibody Production Services.Mammalian Transient Expression Services. ![]() SARS-CoV-2 Variant Detection Antibodies.Immunodetection for Pan Influenza NP Antigens.SARS-CoV-2 Prefusion Trimeric Spike Variant.Hydrogels nerve guidance conduits photochemistry protein immobilization spinal cord injury repair. This study demonstrates a promising hydrogel scaffold for SCI repair and provides the first understanding of the photoimmobilization of adhesive protein in a 3D hydrogel conduit concerning its functions on spinal cord tissue restoration. Histological analysis suggests that the designed hydrogel scaffold provides a favorable biological niche for neuronal regeneration, thus producing directional neuron tissue and promoting the repair of SCI. After implantation in transected spinal cord, the optimized hydrogel scaffold is found to improve the locomotion recovery of rats 12 weeks after spinal cord injury (SCI). In vitro coculture assay of neural stem cells (NSCs) shows that photoimmobilization of collagen significantly improves the adhesion and survival of NSCs in the conduit, and exhibits synergistic effect with the sustainable release of growth factor. In this study, phenyl azide photchemistry and optical fiber technology are first used to localize adhesive protein on the inner surface of the nerve guidance conduit in a 3D hydrogel scaffold. However, it is seldom applied in 3D tissue engineering and regenerative medicine due to the attenuation of light. Photochemistry is considered to be a promising strategy for hydrogels to mimic the complex and dynamic properties of natural extracellular matrix. 5 Bone and Trauma Center, The Third Affiliated Hospital of Chongqing Medical University (Gener Hospital), Chongqing, 401120, China.4 National Department of Neurosurgery and Key Laboratory of Neurotrauma, Southwest Hospital, Third Military Medical University (Army Medical University), 29# Gao Tan Yan Street, Chongqing, 400038, P.3 Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University (Army Medical University), 30# Gao Tan Yan Street, Chongqing, 400038, P.2 National and Regional United Engineering Laboratory of Tissue Engineering, Department of Orthopedics, Southwest Hospital, Third Military Medical University (Army Medical University), 29# Gao Tan Yan Street, Chongqing, 400038, P.1 Optogenetics and Synthetic Biology Interdisciplinary Research Center, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130# Meilong Road, Shanghai, 200237, China. ![]()
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